The role of nicotinic acetylcholine receptors in Alzheimer’s disease.
Role of the nicotinic receptor in Alzheimer’s disease pathology
There is experimental and biomedical evidence that the nicotinic acetylcholine receptor (nAChR) is implicated in Alzheimer’s Disease (AD) pathology. The only reasonably efficient FDA approved treatment for early stage AD, blockers of acetylcholine esterase […]
2013-2017 PhD in Neuroscience, University of Bristol
Thesis: Nicotinic receptor regulation of glutamatergic transmission essential for recognition memory
Supervisors: Prof E.C Warburton, Prof Z.I Bashir, & Prof S. Wonnacott
2010-2013 BSc (Hons) in Neuroscience, University of Bristol
Dissertation: “An investigation into plasticity in Area TE”
Units: Synaptic plasticity, Molecular Neuroscience and Neuropsychiatric diseases
▪ In vitro electrophysiology: Whole-cell voltage clamp, current-clamp, and optogenetics
▪ Behavioural testing: Spontaneous recognition memory in rodents
▪ Stereotaxic surgery: Chronic cannulation, viral transfection, and lesion
▪ Histology: Transcardial perfusion, cryostat, light and fluorescence microscopy
2017 Tocris award for final year PhD presentation
2016 School of physiology, pharmacology and neuroscience poster presentation award
2012 Pfizer prize
Publications & Poster Presentations
Sabec M.H, Wonnacott S, Warburton E.C & Bashir Z.I. Nicotinic acetylcholine receptors control encoding and retrieval of associative recognition memory through plasticity in the medial prefrontal cortex. Submitted
Sabec M, et al. The opposing influences of nicotinic acetylcholine receptor subtypes in the medial prefrontal cortex. Society for Neuroscience, San Diego USA, 2016.
Sabec M, et al. α7 and α4β2 nicotinic receptors in the prefrontal cortex control different aspects of associative recognition memory in rats. British Neuroscience Association, Edinburgh UK, 2015.
Sabec M, et al. Nicotinic receptors exert bidirectional modulation of of hippocampal-medial PFC synaptic plasticity. European Synapse Meeting, Bristol UK, 2015