Epi-Med: synthesis and biological evaluation of new active molecules against MLL-rearranged leukaemia.
Rearranged Mixed Lineage lLukaemia (MLLr) is a form of leukaemia representing approximately 75% of paediatric acute leukaemia and 10% of adult leukaemia (AML and ALL), with a very poor prognosis of survival at 5 […]
EpiKillMal- Use of DNA methyltransferase inhibitors to kill drug-resistant malaria parasites –
Malaria remains a major global health problem due to the increasing spread of drug resistance and more than 400,000 deaths per year. New drugs that target multidrug resistant parasites are of highest priority. The […]
Targeting Malaria Epigenetics
Malaria is a tropical disease due to a parasite named Plasmodium. It is a global health problem, still causing more than 450.000 deaths each year (mostly African children) and over 200 million infections (http://www.who.int/malaria/en/). […]
2020Bisubstrate inhibitors: the promise of a selective and potent chemical inhibition of epigenetic ‘writers’, Epigenomics, Sep. 2020.
2020Bisubstrate inhibitors: the promise of a selective and potent chemical inhibition of epigenetic ‘writers’., Epigenomics 2020 Sep; 12(17): 1479-1482.
2020Bisubstrate-Type Chemical Probes Identify GRP94 as a Potential Target of Cytosine-Containing Adenosine Analogs., ACS Chem Biol 2020 04; 15(4): 952-961.
2019DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites., ACS Cent Sci 2020 Jan; 6(1): 16-21.
2019Espoirs et promesses de la méthylation de l’ADN et des histones comme cibles anticancéreuses, .
2019[Chemical targeting of DNA and histone methylation in cancer: Novelties, hopes and promises]., Bull Cancer 2019 Oct; 106(10): 823-833.