I obtained my PhD in Immunology in 2013 from the Experimental and Molecular Immunology and Neurogenetics Laboratory (CNRS, Orléans, France), working under the supervision of Isabelle Couillin. I studied the molecular activation mechanisms of NRLP3 inflammasome by using in vitro approach and sterile lung inflammation murine models. My first post-doctoral research position was in March 2014 with Caroline Demangel at Institut Pasteur, Paris. I investigated the molecular mechanism of action of mycolactone, the major virulence factor of Mycobacterium ulcerans the causative agent of Buruli ulcer, which is a skin disease emerging in tropical countries. I participated in describing the potential of mycolactone-derived structures as prospective immunosuppressants. I demonstrated that mycolactone directly targets the Sec61 translocon, thus identifying the mechanism underpinning the anti-inflammatory and proapoptotic properties of mycolactone. My second post-doctoral fellowship was June 2019 where I joined the Biology and Immunology of Malaria Unit at the Center of Immunology of Infectious Diseases, Paris. Under the supervision of Valérie Soulard, I investigated the immune response and the proteomics of Plasmodium berghei and P. falciparum liver stage parasites. In 2021 I also worked with Olivier Silvie leader of the same laboratory, where I studied a Plasmodium propeller domain protein to prevent malaria liver stage infection.
In September 2022 I returned to the Pasteur Institute in Paris, where I joined Biology of Host-parasite Interactions – Liver group led by Liliana Mancio where I have the pleasure to continue to participate in malaria research.
