In 2003, Jeanne got a master degree in cellular and molecular biology from the Université du Languedoc in Montpellier. She did her internship training at Transgene SA in Strasbourg where she studied the expression of a transgene in adenoviral vectors.
She joined the Institut Pasteur in 2003 as a research engineer under the supervision of Fabrice Agou in the Unité de Biochimie Structurale et Cellulaire lead by Pr Michel Véron.
She investigated the role of NEMO in the IKK complex activation which plays a crucial role in the NF-KB pathway. NEMO represents an interesting target as the NF-KB pathway is involved in several types of cancer and autoimmune disorders. She was a leading partner in a collaboration with the pharmaceutical company Servier in order to identify and optimize small molecule inhibitors of NEMO. She developed two fluorescent based screening assays (TR-FRET and fluorescence polarization) and led the tech transfer to the Servier screening facility. She also set up cell-based assays to determine the potency of the chemicals hits on the NF-kB pathway.
In 2012, she joined the High Throughput Screening and Spectroscopy Center (HTSRC) at the Rockefeller University in New York as a research support specialist. She acquired a strong expertise in state-of-art High Throughput and High Content Screen techniques (HTS/HCS) that support drug discovery effort and mechanistic studies. In collaboration with students and researchers, she designed, developed and optimized biochemical and cell-based assays for various targets and supervised 30+ medium and high-throughput screening campaigns. She was specifically in charge of the design of high content screening assays. Beside her service assignments, she initiated her own project that led to the development of a novel image-based assay to assess the cytotoxicity of small molecules. This work was presented in a poster in the High Content Analysis (HCA) meeting in San Diego in 2014 and was published SLAS Discovery in 2017.
She returned to the Institut Pasteur in 2019 where she joined the Chemogenomic and Biological Screening platform (PF-CCB) directed by Fabrice Agou. With her strong experience, she assists research teams in their project from the development of HTS/HCS assays to their lead optimization.
For any further questions, please don’t hesitate to contact her.