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  • Director of Center
  • Director of Department
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About

We are using in vitro and in vivo reprogramming system to investigate how cellular plasticity is regulated during physiological and pathological processes. Our aim is to understand how aberrant cellular plasticity is induced during tumorigenesis and how to modulate cellular plasticity for regeneration especially in ageing related diseases.

Transversal Projects

Cancer Initiative

With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]

Ageing & Longevity

According to the WHO, the global percentage of people aged of more than 60 years will double from 11 to 22% between 2000 and 2050. Nowadays most of the elderly die of non-transmissible diseases […]

LabEx Revive – Regenerative biology & medicine

Rationale and Objectives of Revive Consortium Major advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. The […]

Projects

Project
Ongoing
16 Members

Organ-on-Chip Center

Samy Gobaa (PI)

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]
Project
Ongoing
4 Members

Cellular plasticity and Ageing

Han Li (PI)

Ageing is associated with losing normal cellular plasticity (regeneration capacity) while acquiring abnormal cellular dys-plasticity (cancer). Cellular reprogramming is associated with a gain in the potential for differentiation and self-renewal. Could common pathways be […]
Project
ongoing
1 Member

Cellular plasticity and Cancer

Han Li (PI)

Aberrant cellular plasticity (“dys-plasticity”) could occur in vivo, which contributes significantly to disease development, especially in cancer. Recently, we showed p27-/- cells are dysplastic due to the derepression of Sox2, an essential pluripotency gene. […]

CV

2014 – present  G5 Group Leader, Institut Pasteur

2012 – 2014       Staff scientist, Tumor Suppression Group, Spanish National Research Centre

                           Madrid, Spain

2007 – 2012       Postdoctral Fellow, Tumor Suppression Group, Spanish National Research Centre

                           Madrid, Spain

2001 – 2007       Ph.D. in Molecular Medicine, University of Texas Health Science Center at San Antonio

                           San Antonio, Texas, USA

1995 – 1999       Bachelor in Ecology, FuDan University,

                                  Shanghai, China

Publications

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