I received my PhD from Sapienza-University of Rome (Italy) in 2014. I investigated the regulation of HLA-E molecule expression during the monocyte-to-macrophage differentiation process as well as their role in the crosstalk between mononuclear phagocytes and Natural Killer cells. I also participated in a project whose main objective was to study the expression and role of ADAR enzymes in human myeloid leukemia cells. I then joined the Immunology of Fungal Infection unit at the Pasteur Institute as a Postdoctoral researcher in December 2015 where I’m studying the b–glucans immunobiology. My research interests focus, in particular, on deciphering the b–glucan-mediated modulation of mononuclear phagocyte functions and of innate immune responses. These natural compounds have recently gained significant attention in the biomedical field for their antibacterial, antifungal and anticancer activities. A better understanding of their immunomodulating properties is, therefore, essential to make them potential candidates as therapeutic agents.
β-glucan imprinting of macrophages
The enhanced responsiveness observed in human monocytes and mediated by β‑glucan priming is directed towards several other pathogens that are not obligatory fungal-related. This enhanced responsiveness coined training is translated by increased pro-inflammatory cytokines […]
β-glucan regulation of innate host defence
β-glucan, the most abundant fungal cell wall polysaccharide in C. albicans, has gained much attention from the scientific community in the last few decades for its fascinating but not yet fully understood immunobiology. Study […]
EDUCATION AND WORK EXPERIENCE
- 2015-present: Post-Doctoral Fellow in the department of Immunology/Mycology, Institut Pasteur, Paris (France)
- 2014-2015: Post-Doctoral Fellow in the department of Biology and Biotechnology, Sapienza-University of Rome (Italy)
- 2010-2014: PhD in the department of Biology and Biotechnology, Sapienza-University of Rome (Italy)
- 2004-2010: Master’s degree in Biology Applied to Biomedical Research and Bachelor’s degree in Biological Sciences, Sapienza-University of Rome (Italy)
2020β-Glucan-induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies., J Clin Invest 2020 09; 130(9): 4561-4573.
2018The Complexity of Fungal β-Glucan in Health and Disease: Effects on the Mononuclear Phagocyte System, Front. Immunol., 16 April 2018 | https://doi.org/10.3389/fimmu.2018.00673.
2018Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles, Eur J Immunol. 2018 Jan 5. doi: 10.1002/eji.201747224.
2017RNA editing signature during myeloid leukemia cell differentiation, Leukemia. 2017 Dec;31(12):2824-2832. doi: 10.1038/leu.2017.134. Epub 2017 May 9..
2015Regulation and trafficking of the HLA-E molecules during monocyte-macrophage differentiation, J Leukoc Biol. 2016 Jan;99(1):121-30. doi: 10.1189/jlb.1A0415-172R. Epub 2015 Aug 26..
2014Single nucleotide polymorphisms in the 3’UTR of VPAC-1 cooperate in modulating gene expression and impact differently on the interaction with miR525-5p, PLoS One. 2014 Nov 12;9(11):e112646. doi: 10.1371/journal.pone.0112646. eCollection 2014..