After obtaining my BTS (Brevet de Technicien Supérieur), I started to work for the VIRBAC Laboratory on a research project for industry, carried out in collaboration with the CNRS. 10 years later, I joined the Virology department of Institute Pasteur in the unit of Professor Michel BRAHIC, where under the supervision of Dr Jean-François BUREAU, I studied the genetic susceptibility of viral infection, more precisely the functional study of a locus of sensitivity for demyelinating disease induced by Theiler ‘s murine encephalomyelitis virus (a model of multiple sclerosis). In 2006, I joined the unit of Dr Marie-Annick BUENDIA, where I worked under the supervision of Dr Yu WEI where I studied the role of the FHL2 protein (a transcriptional coactivator) in various biological processes associated with hepatic tumorigenesis. Moreover, I worked on the validation of candidate genes in hepatocellular carcinoma (collaborative project with 16 European laboratories: MODHEP). I have now joined the LEVAYER Romain laboratory in the department of Developmental and Stem Cell Biology where I hope my experience in molecular biology for the construct of various tools could help for the research projects.
Commitment to apoptosis and the orchestration of cell clearance
Despite the detailed characterisation of the molecular players of apoptosis, its orchestration and fine regulation in multicellular contexts is not well understood. While apoptosis is often considered as a simple binary process, there are nowadays many evidences showing […]
ERC-2017-StG_CoSpaDD: Competition for space in development and disease
Despite our deep knowledge of the pathways regulating cell proliferation, growth and survival, we still do not understand how single cells can match their behavior to properties of the entire tissue (including its size and shape). Mechanical […]
Molecular mechanisms regulating hepatitis B virus replication and liver carcinogenesis
Despite the existence of safe and efficient vaccines for more than twenty-five years, hepatitis B remains a public health problem of worldwide importance. It is currently estimated that 240 million people are chronic carriers […]
2024Patterned apoptosis has an instructive role for local growth and tissue shape regulation in a fast-growing epithelium., Curr Biol 2024 Jan; (): .
2023NDP52 mediates an antiviral response to hepatitis B virus infection through Rab9-dependent lysosomal degradation pathway., Nat Commun 2023 Dec; 14(1): 8440.
2022Microtubule disassembly by caspases is an important rate-limiting step of cell extrusion., Nat Commun 2022 Jun; 13(1): 3632.
2021Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination., Dev Cell 2021 06; 56(12): 1700-1711.e8.