Dandan is a PhD student in the Zurzolo lab, working under the supervision of Stéphanie Lebreton. Her project is focused on deciphering the molecular components governing Golgi clustering of GPI-APs in polarized epithelial cells. More specifically, she employs confocal microscopy, western blotting, and velocity gradients to study the role of cab45, a luminal Golgi protein that binds to calcium and a master regulator of GPI-AP clustering.
Mechanisms of GPI-anchored protein apical sorting and plasma membrane organization in polarized epithelial cells.
Mechanisms of GPI-anchored protein apical sorting and plasma membrane organization in polarized epithelial cells. Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are membrane proteins with a range of conserved functions (e.g. enzymes, receptors, adhesion molecules, and surface […]
2023Calcium-binding Cab45 regulates the polarized apical secretion of soluble proteins in epithelial cells., Mol Biol Cell 2023 Jul; 34(8): br12.
2021Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in polarized epithelial cells., Proc Natl Acad Sci U S A 2021 Aug; 118(33): .