My training is as an evolutionary virologist. I am interested in the processes’ of virus evolution (emergence, adaptation) at the theoretical level, but also at a more applied level understanding the interaction between the viral quasispecies and the immune system. At this moment, I am in charge of vertebrating all the projects in which our group is implicated, as well as increasing the data analysis capabilities of the IP international network.
Dengue is an important pathogen for several of the IPIN (Cambodia, Senegal, and Uruguay), as well as IP Paris. One of the most challenging problems that we are now facing is to […]
In collaboration with other groups in IP Paris and the Broad Institute, we are analyzing the Deep Sequencing data obtained from the ongoing epidemic in Africa. The knowledge obtained from this analysis will help […]
In collaboration with the group of Anavaj Sakuntabhai (IP Paris) and the CERMES (Niger) we will perform GWAS on longitudinal samples coming from the Senegal Cohort Study and Niger. Longitudinal GWAS are […]
Persimune is a small consortium that has received funding from the Danish Government to create a Centre of Excellence in Personalized Medicine of Infectious Complications in Immune Deficiency. It’s a 10 years project led by […]
2015Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype, PLoS Pathog. 2015 May;11(5):e1004838.
2015Deep sequencing analysis of viral infection and evolution allows rapid and detailed characterization of viral mutant spectrum, Bioinformatics 2015 Jul;31(13):2141-50.
2014Emergence and transmission of arbovirus evolutionary intermediates with epidemic potential, Cell Host Microbe 2014 Jun;15(6):706-16.
2012Coxsackievirus B3 mutator strains are attenuated in vivo, Proc. Natl. Acad. Sci. U.S.A. 2012 Aug;109(34):E2294-303.
2011RNA virus population diversity: implications for inter-species transmission, Curr Opin Virol 2011 Dec;1(6):643-8.
2011Arbovirus high fidelity variant loses fitness in mosquitoes and mice, Proc. Natl. Acad. Sci. U.S.A. 2011 Sep;108(38):16038-43.
2011Isolation of fidelity variants of RNA viruses and characterization of virus mutation frequency, J Vis Exp 2011;(52).
2010Interplay between RNA structure and protein evolution in HIV-1, Mol. Biol. Evol. 2011 Apr;28(4):1333-8.
2010Dynamics of in vitro fitness recovery of HIV-1, J. Virol. 2011 Feb;85(4):1861-70.
2010Initial fitness recovery of HIV-1 is associated with quasispecies heterogeneity and can occur without modifications in the consensus sequence, PLoS ONE 2010;5(4):e10319.
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