The team aims to explore the regulatory mechanisms and roles of chromosome folding in yeast and bacteria through a combination of state-of-the-art techniques including synthetic biology, chromosome conformation capture derivatives, and engineered chromosomal systems. We aspire to sustain a creative, dynamic and friendly environment, providing all members with the freedom, resources and support to conduct their projects and gain momentum for their future careers. The ability to work in a collaborative, multi-disciplinary environment is essential: microbiologists, geneticists, physicists and computer scientists work synergistically in the lab and we also enjoy well-established collaborations in these fields. We expect future lab members to take full advantage of this environment to tackle ambitious, exciting projects.
The laboratory is recruiting several persons to work on an ERC CoG project, building upon recent studies [1–5], to better characterize and understand the functional organization of yeast and bacterial genomes. We will try to further decipher the fundamental processes that drive genome reorganization during transcription, replication, and segregation events. This will be done by combining existing tools, as well as through the development of new methods.
We are recruiting:
- A postdoc with experience or interest in yeast chromosomal biology
- A postdoc with experience in bioinformatics/informatics
- An lab technician/engineer with expertise in yeast and/or bacteria biology
For the postdoc positions we are welcoming applicants from all backgrounds including biophysics and biostatistics. The only requirement is a strong interest, and ideally a publication track record, in working at the interface between these disciplines and experimental chromosome biology. Funding is for 2 years, with a good possibility of extension.
The technician/engineer should have a strong background in implementing basic and advances molecular biology approaches, including high-throughput sequencing library preparation, ChIP, cloning, etc. The position is funded for 3 years.
Candidates should email a CV, statement of research interests (motivation letter) and names of two references to Romain Koszul (firstname.lastname@example.org). Received applications will be reviewed immediately. Starting dates as early as June 2018 but flexible.
Recent lab publications
- 2018, Cell, 172, Lioy, V.S. et al. Multiscale Structuring of the E. coli Chromosome by Nucleoid-Associated and Condensin Proteins
- 2017 EMBO J., Lazar‐Stefanita, L. et al., Cohesins and condensins orchestrate the 4D dynamics of yeast chromosomes during the cell cycle
- 2017 Science 355, Mercy, G. et al., 3D organization of synthetic and scrambled chromosomes
- 2017 bioRxiv DOI: 10.1101/169847 Muller, H. et al. Redesigning chromosomes for optimized Hi-C assay provides insights on loop formation and homologs pairing during meiosis.
- 2015, Mol. Cell, 59, Marbouty, M. et al., Condensin- and Replication-Mediated Bacterial Chromosome Folding and Origin Condensation Revealed by Hi-C and Super-resolution Imaging