The development of effective broadly reactive vaccination and treatment strategies against emerging and re-emerging RNA viruses and in particular, against influenza viruses requires a better understanding of the complex interplay between the virus and the host immune system. The first line of defence against viral infections involve the host pattern recognition receptors (PRRs) that detect specific molecular patterns exclusively found in pathogens and initiate an adequate immune response. Among them, the RIG-I-like receptors (RLRs) are ubiquitously expressed RNA binding proteins that detect viral and some host RNAs in the cytosol to initiate innate antiviral responses. The development of RLR agonists or compounds targeting the RLR signalling pathway are promising therapeutic strategies, as they can modulate host cell functions early upon viral infection and eventually stop it. Our RModSignaling project aim at defining the structural and biochemical composition (primary sequence and chemical modification profiles) of RLR-specific RNA ligands for different influenza viruses.
- Virology (strong background)
- Molecular and cellular biology (strong background)
- Biochemistry and organic chemistry (big plus)
- Immunology (big plus)
- Bioinformatics (big plus)
- Advanced English level required
Institute Pasteur of Paris. The project will be performed in close collaboration between Virology and Chemistry groups of the Institut Pasteur in Paris, Technology Development Platform (Institut Pasteur, Korea), and UMR 7365 CNRS of the University of Lorraine.
Funding from Institut Pasteur (PTR).
Type of Contract : CDD
Contract Period : 24 months
Expected date of employment : 1 January 2022
Proportion of work : Full time
Desired level of education : PhD
Experience required : 3 to 5 years
Send a single pdf document with a detailed CV, a cover letter, and the names and contacts of three references. Materials should be emailed as a single PDF file to the principal investigator Anastasia Komarova (email@example.com), who can be reached for informal inquiries about the project and the research unit.