Interested in discovering how trypanosomes undergo antigenic variation? If the answer is yes – we have a postdoctoral position available in the Trypanosome Molecular Biology group with Lucy Glover. In our group we study how the trypanosomes control expression of the variant surface glycoprotein from the fly to the mammalian host, and the the role of DNA repair and recombination in antigenic variation and immune evasion in African trypanosomes We are located in the Department of Parasites and Insect Vectors at the Institute Pasteur in Paris, which provides an excellent international scientific environment and state-of-the-art core facilities including high throughput sequencing, and imaging technologies.
The project will study the role of the VEX complex (PMID: 31289266; PMID: 27226299) in regulating the expression of variant surface glycoproteins in metacyclic trypanosomes in the Tsetse fly and how this influences mammalian infection. Successful applicants are expected to manage multiple tasks, have good organizational skills, and a willingness to work outside their core expertise. During this project you will employ techniques such as single-cell RNA sequencing, super-resolution microscopy, ChIP-Seq and transcriptomics.
Candidate qualifications
Recent PhD degree in any area of Molecular Biology or Life Sciences with at least one first-author publication either published or in press in a peer reviewed journal is essential.
Expertise in several of the following areas is required: molecular and cellular biology, cell culture, microscopy and image analysis, flow cytometry, next generation sequencing and functional genomics.
Experience in trypanosome biology and animal models is desirable but not required.
The applicant is expected to have good communication skills and excellent command of spoken and written English.
Good publication record and ability to work in team are also important.
Applicants should submit the following information (PDF file formats preferred) to lucy.glover@pasteur.fr by the 30 January 2020
- Curriculum vitae
- List of publications and communications
- Brief statement of research interests
- Names and contact information of at least two referees