Post doctoral position is available starting Oct 1, 2023, in the Stress Adaptation and Metabolism (SAMe) Unit directed by Prof. F. Barras at the Institut Pasteur, Paris.
The research program is focused on how tRNA modification (thiolation) acts as stress sensing device linking metabolism and translation. Sulfur availability, iron limitation, and oxidative stress range among the studied stress and Fe-S clusters are potential key actors in the sensing process. The project is carried out using E. coli as a model but the process being highly conserved, questions addressed might have major impact for the understanding of the molecular factors at the basis of a number of diseases.
Research would include performing bacterial genetics, transcriptomics, proteomics, flow cytometry and imaging analyses. Expertise in biochemistry and redox biology could also be an advantage. The program is part of a multidisciplinary ANR-funded project and will offer possibilities of collaboration with biophysists, structuralists, and experts in yeast and mammalian redox biology.
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