Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research
Event

Department of Microbiology – “The role of microbial pathogenesis in genome instability of human host: Deregulation of DNA repair and mitochondrial bioenergetics” by Lene Juel Rasmussen, Center for Healthy Aging, University of Copenhagen (Denmark)

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
21
Apr 2017
Time
11:30:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: Auditorium François Jacob
Location
2017-04-21 11:30:00 2017-04-21 00:30:00 Europe/Paris Department of Microbiology – “The role of microbial pathogenesis in genome instability of human host: Deregulation of DNA repair and mitochondrial bioenergetics” by Lene Juel Rasmussen, Center for Healthy Aging, University of Copenhagen (Denmark) It is well known that environmental factors such as chemicals and radiation cause DNA damage. In contrast, the consequences of bacterial infection on the integrity of host DNA are poorly understood. We show that […] Institut Pasteur, Rue du Docteur Roux, Paris, France Eliette Touati eliette.touati@pasteur.fr

About

It is well known that environmental factors such as chemicals and radiation cause DNA damage. In contrast, the consequences of bacterial infection on the integrity of host DNA are poorly understood. We show that two pathogens (Helicobacter pylori and Enterococcus faecalis) are implicated in the induction of genomic instability in both nuclear and mitochondrial DNA (mtDNA) of gastric epithelial cells. Instability in nuclear DNA is coupled to down-regulation of central DNA repair activities that includes DNA mismatch repair (MMR). By down-regulating MMR pathways, bacterial infections have the potential to inflict direct changes in the DNA of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, bacterial infections generate instability in mtDNA by lowering mtDNA content as well as by decreasing complex I activity. Based on our results, we propose that bacterial infections promote genomic instability by at least three different mechanisms: (1) by a combination of increased endogenous DNA damage and decreased repair activities; (2) by induction of mutations in the mtDNA; and (3) by the generation of a transient mutator phenotype that induces mutations in the nuclear genome.

Location

Building: Auditorium François Jacob
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France