The Aspergillus fumigatus CrzA and ZipD Transcription Factors Are Involved in Calcium Metabolism and the Caspofungin Paradoxical Effect - Gustavo Goldman - Research - Institut Pasteur

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“The impact of antibiotic treatment on resistome and novel treatment strategies”

Amira Software Workshop – Institut Pasteur – 19th of June 2019

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

20

Jun 2019

Time

14:00:00

Institut Pasteur, Rue du Docteur Roux, Paris, France

Address

Building: Fernbach RDC

Location

2019-06-20 14:00:00 2019-06-20 15:00:00 Europe/Paris The Aspergillus fumigatus CrzA and ZipD Transcription Factors Are Involved in Calcium Metabolism and the Caspofungin Paradoxical Effect – Gustavo Goldman Gustavo Goldman – Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo Systemic Aspergillus fumigatus infections are often accompanied by high mortality rates. The fungal cell wall is important for infection as it […] Institut Pasteur, Rue du Docteur Roux, Paris, France Guilhem Janbon guilhem.janbon@pasteur.fr

About

Gustavo Goldman – Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo

Systemic Aspergillus fumigatus infections are often accompanied by high mortality rates. The fungal cell wall is important for infection as it has immunomodulatory and immunoevasive properties. Paradoxical growth of A. fumigatus in the presence of high concentrations of the cell wall-disturbing agent caspofungin has been observed for more than a decade, although the mechanistic nature of this phenomenon remains largely uncharacterized. Here, we show that the CWI pathway components MpkA and RlmA as well as the calcium/calcineurin-responsive transcription factor CrzA regulate the expression of cell wall biosynthetic genes during the caspofungin paradoxical effect (CPE). Furthermore, an additional, novel calcium/calcineurin-responsive transcription factor was identified to play a role in cell wall biosynthesis gene expression during the CPE. This work paints a crucial role for calcium metabolism in the CPE and provides further insight into the complex regulation of cell wall biosynthesis, which could ultimately lead to the development of more efficient antifungal therapies.

Website: https://bv.fapesp.br/en/pesquisador/480/gustavo-henrique-goldman/

Contact : Guilhem Janbon (guilhem.janbon@pasteur.fr)

Location

Building: Fernbach RDC
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France

Published on: 05 Jun 2019

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