Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Lydie Couturier , Institut Pasteur
Organes sensoriels en développement chez la drosophile
Event

SEMINAR ” Epigenetic mechanisms in early mammalian development ” by Maria Elena Torres-Padilla

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
17
Mar 2017
Time
12:00:00
25 Rue du Docteur Roux, Paris, France
Address
Building: J.Monod (#66)
Location
2017-03-17 12:00:00 2017-03-17 13:15:00 Europe/Paris SEMINAR ” Epigenetic mechanisms in early mammalian development ” by Maria Elena Torres-Padilla   Department of Developmental and Stem Cell Biology 2017 Seminar Series Friday 17th March — at 12.00 pm @ Amphi Jacques Monod (Bât.66) SEMINAR ” Epigenetic mechanisms in early mammalian development “ Invited Speaker […] 25 Rue du Docteur Roux, Paris, France Han Li han.li@pasteur.fr

About

 

Department of Developmental and Stem Cell Biology

2017 Seminar Series

Friday 17th March — at 12.00 pm @ Amphi Jacques Monod (Bât.66)

SEMINAR ” Epigenetic mechanisms in early mammalian development “

Invited Speaker Maria Elena Torres-Padilla

IES – Institute of Epigenetics ans Stem Cells
Helmholtz Zentrum München- Germany

Abstract : In mammals, the terminally differentiated sperm and oocyte fuse to create a totipotent zygote upon fertilisation. The mechanisms underlying the epigenetic reprogramming towards totipotency that follows fertilisation are not fully understood, and the molecular features of totipotent cells remain scarce. Embryonic cells remain totipotent only for a restricted time window. During this time, embryonic cells are characterised by an atypical chromatin structure and reactivation of specific families of retrotransposons. Recently, it was reported that totipotent-like cells arise in ES cell cultures in vitro. Like in the embryo, these cells are characterised by the expression of MERVL LTR retrotransposons. To address how the expression of these elements is regulated during the transition between totipotent and pluripotent states, we first examined histone modifications and chromatin structure in early mouse embryos. Remarkably, we have found that specific features of embryonic chromatin are also present in totipotent-like cells in vitro. Based on this analysis, we have begun to decipher key molecular regulators of repetitive elements in the embryo. Our results have identified candidate proteins that regulate chromatin function and expression of these elements and show that they can induce totipotency. We are currently examining the role of these molecules in sustaining totipotency in the embryo. We will present our latest results that reveal a new role for chromatin integrity in promoting epigenetic reprogramming and sustaining molecular features of totipotent cells.

 

Hosted by Han Li

Location

Building: J.Monod (#66)
Address: 25 Rue du Docteur Roux, Paris, France