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SEMINAR ” Left-Right asymmetry in Drosophila: from molecular to organism chirality ” by Stéphane Noselli

Microfluidics Club at Pasteur Third Seminar: Dr. Gilgueng HWANG

© Institut Pasteur/Marco Gualtieri & Pauline Spéder

Event

SEMINAR ” Epigenetic mechanisms in early mammalian development ” by Maria Elena Torres-Padilla

Department of: Developmental and Stem Cell Biology

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

17

Mar 2017

Time

12:00:00

25 Rue du Docteur Roux, Paris, France

Address

Building: J.Monod (#66)

Location

2017-03-17 12:00:00 2017-03-17 13:15:00 Europe/Paris SEMINAR ” Epigenetic mechanisms in early mammalian development ” by Maria Elena Torres-Padilla Department of Developmental and Stem Cell Biology 2017 Seminar Series Friday 17th March — at 12.00 pm @ Amphi Jacques Monod (Bât.66) SEMINAR ” Epigenetic mechanisms in early mammalian development “ Invited Speaker […] 25 Rue du Docteur Roux, Paris, France Han Li han.li@pasteur.fr

About

Department of Developmental and Stem Cell Biology

2017 Seminar Series

Friday 17th March — at 12.00 pm @ Amphi Jacques Monod (Bât.66)

SEMINAR ” Epigenetic mechanisms in early mammalian development “

Invited Speaker ⇒ Maria Elena Torres-Padilla

IES – Institute of Epigenetics ans Stem Cells
Helmholtz Zentrum München- Germany

Abstract : In mammals, the terminally differentiated sperm and oocyte fuse to create a totipotent zygote upon fertilisation. The mechanisms underlying the epigenetic reprogramming towards totipotency that follows fertilisation are not fully understood, and the molecular features of totipotent cells remain scarce. Embryonic cells remain totipotent only for a restricted time window. During this time, embryonic cells are characterised by an atypical chromatin structure and reactivation of specific families of retrotransposons. Recently, it was reported that totipotent-like cells arise in ES cell cultures in vitro. Like in the embryo, these cells are characterised by the expression of MERVL LTR retrotransposons. To address how the expression of these elements is regulated during the transition between totipotent and pluripotent states, we first examined histone modifications and chromatin structure in early mouse embryos. Remarkably, we have found that specific features of embryonic chromatin are also present in totipotent-like cells in vitro. Based on this analysis, we have begun to decipher key molecular regulators of repetitive elements in the embryo. Our results have identified candidate proteins that regulate chromatin function and expression of these elements and show that they can induce totipotency. We are currently examining the role of these molecules in sustaining totipotency in the embryo. We will present our latest results that reveal a new role for chromatin integrity in promoting epigenetic reprogramming and sustaining molecular features of totipotent cells.

Hosted by Han Li

Location

Building: J.Monod (#66)
Address: 25 Rue du Docteur Roux, Paris, France

Published on: 09 Mar 2017 • Modified on: 10 Mar 2017

(function($) { /* * render_map * * This function will render a Google Map onto the selected jQuery element * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $el (jQuery element) * @return n/a */ function render_map( $el ) { var MY_MAPTYPE_ID = 'custom_style'; var featureOpts = [{"stylers":[{"hue":"#0088ff"}]}]; var styledMapOptions = { name: 'Custom Style' }; var customMapType = new google.maps.StyledMapType(featureOpts, styledMapOptions); // var var $markers = $el.find('.marker'); // vars var args = { zoom : 16, scrollwheel : false, center : new google.maps.LatLng(0, 0), mapTypeId : google.maps.MapTypeId.ROADMAP, mapTypeId : MY_MAPTYPE_ID }; // create map var map = new google.maps.Map( $el[0], args); map.mapTypes.set(MY_MAPTYPE_ID, customMapType); // add a markers reference map.markers = []; // add markers $markers.each(function(){ add_marker( $(this), map ); }); // center map center_map( map ); } /* * add_marker * * This function will add a marker to the selected Google Map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $marker (jQuery element) * @param map (Google Map object) * @return n/a */ function add_marker( $marker, map ) { // var var latlng = new google.maps.LatLng( $marker.attr('data-lat'), $marker.attr('data-lng') ); //var image = 'https://research.pasteur.fr/wp-content/themes/biologyx2/images/logomap.png'; var myIcon = new google.maps.MarkerImage('https://research.pasteur.fr/wp-content/themes/biologyx2/images/map-pin.png', null, null, null, new google.maps.Size(32,32)); // create marker var marker = new google.maps.Marker({ position : latlng, map : map, icon : myIcon }); // add to array map.markers.push( marker ); // if marker contains HTML, add it to an infoWindow if( $marker.html() ) { // create info window var infowindow = new google.maps.InfoWindow({ content : $marker.html() }); // show info window when marker is clicked google.maps.event.addListener(marker, 'click', function() { infowindow.open( map, marker ); }); } } /* * center_map * * This function will center the map, showing all markers attached to this map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param map (Google Map object) * @return n/a */ function center_map( map ) { // vars var bounds = new google.maps.LatLngBounds(); // loop through all markers and create bounds $.each( map.markers, function( i, marker ){ var latlng = new google.maps.LatLng( marker.position.lat(), marker.position.lng() ); bounds.extend( latlng ); }); // only 1 marker? if( map.markers.length == 1 ) { // set center of map map.setCenter( bounds.getCenter() ); map.setZoom( 15 ); } else { // fit to bounds map.fitBounds( bounds ); } } /* * document ready * * This function will render each map when the document is ready (page has loaded) * * @type function * @date 8/11/2013 * @since 5.0.0 * * @param n/a * @return n/a */ $(document).ready(function(){ $('.acf-map').each(function(){ render_map( $(this) ); }); }); })(jQuery);