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© Institut Pasteur
Cellules dans un embryon de souris
Event

Of cavefish and cavemen. What can we learn from blind, fat fish to keep us healthy. By Nicolas Rohner, Stowers Institute for Medical Research, Kansas City, USA

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
05
May 2017
Time
12:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: MONOD Room: Amphi
Location
2017-05-05 12:00:00 2017-05-05 13:00:00 Europe/Paris Of cavefish and cavemen. What can we learn from blind, fat fish to keep us healthy. By Nicolas Rohner, Stowers Institute for Medical Research, Kansas City, USA Abstract: Understanding the genetic basis of adaptation has broad implications not only for a basic understanding of evolution, but also for human pathologies given that many human diseases are a consequence of mis-adaptation to […] Institut Pasteur, Rue du Docteur Roux, Paris, France Jérôme Gros jerome.gros@pasteur.fr

About

Abstract: Understanding the genetic basis of adaptation has broad implications not only for a basic understanding of evolution, but also for human pathologies given that many human diseases are a consequence of mis-adaptation to modern societies. Cavefish have acquired impressive metabolic adaptations to the food deprived cave environments, such as hyperphagia and insulin resistance. Remarkably, none of these phenotypes are leading to measurable health disadvantages, even when fed ad libitum in the laboratory environment. We hypothesize that cavefish must have co-evolved factors helping them to mitigate the otherwise detrimental health and lifespan effects usually associated with such drastic metabolic alterations. As such, we propose cavefish as a novel system which offers the possibility of identifying genetic pathways that can be protective under extreme nutritional situations, and hence, of someday developing therapies that would limit the impact of these conditions on the health of patients.

Location

Building: MONOD
Room: Amphi
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France