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Seminars Call CryoEM

Microbiology department seminar: Clay Fuqua (Indiana University, USA) ; “Pterin it up: Complex control of surface attachment and biofilm formation in the model pathogen Agrobacterium tumefaciens” ; Friday September 22nd, 11.30am ; Auditorium F. Jacob

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Event

Joint Microbiology, BCI, and Structural Biology and Chemistry Departments seminar: Melanie OTT (UCSF, USA) ; “Understanding SARS-CoV-2 Variants through Reverse Genetics” ; Wenesday 27 September @2.00pm; Jules Bordet room

Member: Carmen Buchrieser

Member: Mélanie Hamon

Member: Paola Arimondo

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

27

Sep 2023

Time

14:00:00

Address

Building: Metchnikoff building Room: Jules Bordet room

Location

2023-09-27 14:00:00 2023-09-27 15:00:00 Europe/Paris Joint Microbiology, BCI, and Structural Biology and Chemistry Departments seminar: Melanie OTT (UCSF, USA) ; “Understanding SARS-CoV-2 Variants through Reverse Genetics” ; Wenesday 27 September @2.00pm; Jules Bordet room Wenesday, September 27th, 2023, at 2.00pm Jules Bordet room Melanie Ott Senior Investigator, Gladstone Institute of Virology and Immunology at the UCSF (University of California San Francisco), Gladstone Institute of Virology and Immunology, […] Carmen Buchrieser carmen.buchrieser@pasteur.fr

Speakers

(Gladstone Institute of Virology and Immunology at the UCSF (University of California San Francisco)

About

Wenesday, September 27^th, 2023, at 2.00pm

Jules Bordet room

Melanie Ott

Senior Investigator, Gladstone Institute of Virology and Immunology at the UCSF (University of California San Francisco),

Gladstone Institute of Virology and Immunology, USA

Invited by Carmen Buchrieser, Mélanie Hamon and Paola Arimondo

“Understanding SARS-CoV-2 Variants through Reverse Genetics”

Abstract:

SARS-CoV-2 continues to circulate with a set of actively evolving subvariants of the Omicron variant. Much attention is focused on mutations in the Spike protein and their immune evasive properties but changes in other structural and non-structural proteins contribute importantly to viral evolution and attenuation. We developed molecular technologies to rapidly and safely assess the functional impact of genome-wide mutations. These include virus-like particles (VLPs), replicons and full-length infectious clones. Here we discuss how signature mutations in Beta, Delta and Omicron variants affect viral fitness and nonstructural and structural protein functions.

Published on: 18 Sep 2023

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