Immune-mediated control of Toxoplasma in human cells – Eva Frickel | Research - Institut Pasteur

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HDR Defense in Virology Department : “Structural studies of viral proteins involved in virus internalization” with Pablo Guardado Calvo

Sphingosine-1-phosphate and cryptococcosis – Maurizio Del Poeta

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

19

Sep 2019

Time

12:00:00

Institut Pasteur, Rue du Docteur Roux, Paris, France

Address

Building: Lwoff

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2019-09-19 12:00:00 2019-09-19 13:00:00 Europe/Paris Immune-mediated control of Toxoplasma in human cells – Eva Frickel Eva Frickel –The Francis Crick Institute, Host-Toxoplasma Interaction Laboratory, London, GB The protozoan parasite Toxoplasma gondii infects a broad range of hosts, with a seroprevalence in man of about 30 percent. It is unclear how Toxoplasma maintains the […] Institut Pasteur, Rue du Docteur Roux, Paris, France Lucy Glover lucy.glover@pasteur.fr

About

Eva Frickel –The Francis Crick Institute, Host-Toxoplasma Interaction Laboratory, London, GB

The protozoan parasite Toxoplasma gondii infects a broad range of hosts, with a seroprevalence in man of about 30 percent. It is unclear how Toxoplasma maintains the intricate balance between survival and host defense. IFNγ, the main cytokine responsible for its control, activates cells to restrict intracellular parasite replication or to kill intracellular Toxoplasma. Our long-term goal is to identify IFNγ-driven novel pathways of host resistance to Toxoplasma in human cells. The pathways we study often also impact bacterial pathogens as well as Toxoplasma. Therefore, the Frickel lab strives to uncover human IFNγ-dependent host defence pathways of broad relevance to eukaryotic and bacterial pathogens.

Host Response to Microbe Analysis: Artificial intelligence-driven image analysis. We developed HRMAn as an intelligent, image-based analysis program that allows for unbiased, quantitative assessment of host-pathogen interactions. HRMAn is a high-performance, user-friendly analysis pipeline designed in KNIME. HRMAn can run on any computer, analyse images from any fluorescent microscope and cater to a wide-range of pathogens without any need for additional coding by the users. The core of HRMAn is its unprecedented neural network-driven analysis of host protein recruitment to pathogens.

your website: https://frickellab.com, https://hrman.org

Contact : Lucy Glover (lucy.glover@pasteur)

Location

Building: Lwoff
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France

Published on: 14 Aug 2019

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