Eva Frickel –The Francis Crick Institute, Host-Toxoplasma Interaction Laboratory, London, GB
The protozoan parasite Toxoplasma gondii infects a broad range of hosts, with a seroprevalence in man of about 30 percent. It is unclear how Toxoplasma maintains the intricate balance between survival and host defense. IFNγ, the main cytokine responsible for its control, activates cells to restrict intracellular parasite replication or to kill intracellular Toxoplasma. Our long-term goal is to identify IFNγ-driven novel pathways of host resistance to Toxoplasma in human cells. The pathways we study often also impact bacterial pathogens as well as Toxoplasma. Therefore, the Frickel lab strives to uncover human IFNγ-dependent host defence pathways of broad relevance to eukaryotic and bacterial pathogens.
Host Response to Microbe Analysis: Artificial intelligence-driven image analysis. We developed HRMAn as an intelligent, image-based analysis program that allows for unbiased, quantitative assessment of host-pathogen interactions. HRMAn is a high-performance, user-friendly analysis pipeline designed in KNIME. HRMAn can run on any computer, analyse images from any fluorescent microscope and cater to a wide-range of pathogens without any need for additional coding by the users. The core of HRMAn is its unprecedented neural network-driven analysis of host protein recruitment to pathogens.
your website: https://frickellab.com, https://hrman.org
Contact : Lucy Glover (lucy.glover@pasteur)