Jeudi 8 octobre 2015 à 11 H 00
Salle Jean-Paul Aubert, rdc bâtiment Fernbach
« Histology informatics: dissecting breast tumour spatial and molecular heterogeneity»
Centre for Evolution and Cancer, The Institute of Cancer Research, London
Division of Molecular Pathology, The Institute of Cancer Research, London
Centre for Molecular Pathology, The Royal Marsden Hospital, London
Tumours develops and evolves in a complex network of neoplastic and normal cells. Understanding how these cells orchestrate in this tumour ecosystem and co-evolve is key to understanding cancer and how drug resistance is acquired. I will discuss the development of histology image analysis technologies in my lab to automatically identify millions of cancer and microenvironmental cell types within in tumours, how we use morphological analysis, spatial statistics and ecological methods to map the spatial and morphological heterogeneity of 1,000 breast tumours, leading to the identification of new histology patterns that predict patient survival and molecular drivers. Our aims are to develop new tools for integrative analysis of histology images and omics data, to understand cancer-stromal interaction as an ecosystem, and to develop objective methodologies for directing cancer therapeutic strategies.