Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research
Event

Cancelled (will be postponed) – Global Health Department Seminar “Molecular insights into host-pathogen reveals potential new therapeutic targets for MRSA and streptococci”

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
13
Jun 2019
Time
14:00:00
28 Rue du Docteur Roux, Paris, France
Address
Building: François Jacob Room: Auditorium Centre François Jacob
Location
2019-06-13 14:00:00 2019-06-13 15:00:00 Europe/Paris Cancelled (will be postponed) – Global Health Department Seminar “Molecular insights into host-pathogen reveals potential new therapeutic targets for MRSA and streptococci” GLOBAL HEALTH DEPARTMENT SEMINAR Nina van Sorge  Associate professor – Division Laboratory, Pharmacy and Biomedical Genetics University Medical Center Utrecht, The Netherlands “Molecular insights into host-pathogen reveals potential new therapeutic targets for MRSA and […] 28 Rue du Docteur Roux, Paris, France Lhousseine Touqui lhousseine.touqui@pasteur.fr

About

GLOBAL HEALTH DEPARTMENT SEMINAR

Nina van Sorge

 Associate professor – Division Laboratory, Pharmacy and Biomedical Genetics

University Medical Center Utrecht, The Netherlands

“Molecular insights into host-pathogen reveals potential new therapeutic targets for MRSA and streptococci”

Jeudi 13 juin 2019 à 14h00

Auditorium Centre François Jacob

Invited by : Lhousseine Touqui (lhousseine.touqui@pasteur.fr

Institut Pasteur – 25, 28, rue du Dr. Roux– 75724 PARIS CEDEX 15

Abstract :

Human Group IIA-Secreted Phospholipase A2 (hGIIA), a potent cationic bactericidal enzyme present in plasma and tissue fluids, is an important innate defense mechanism against Gram-positive bacteria. Gram-positive bacteria vary in their susceptibility to hGIIA, which may limit the efficacy of hGIIA in clearing invading pathogens. Insight into molecular resistance mechanisms of human pathogens provides insight into hGIIA mechanism of action and may open up new avenues for alternative treatments of bacterial infections. We focus on the activity of hGIIA against two formidable human pathogens, Staphylococcus aureus and Group A Streptococcus (GAS).

This presentation will highlight some of our recent findings in this area. First, we have identified that streptococcal cell wall glycopolymers are critical for hGIIA to exert its bactericidal effects (1). Second, our sPLA2-IIA susceptibility studies resulted in the discovery of a structural modification on the GAS rhamnose polysaccharides (2), which likely also has implications for vaccine design in this area. Finally, we identified lspA, encoding a lipoprotein signal peptidase, as a new S. aureus resistance gene against sPLA2-IIA as well as the last-resort antibiotic daptomycin. Furthermore, treatment of methicillin-resistant S. aureus (MRSA) with a LspA inhibitor sensitized bacteria to hGIIA-mediated killing. Therefore, inhibition of LspA may represent an interesting adjunct treatment strategy to sensitize MRSA to both endogenous and synthetic antibiotics.

References

  1. V. P. van Hensbergen et al., Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects. PLoS Pathog 14, e1007348 (2018).
  2. R. J. Edgar et al., Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides. Nat Chem Biol 15, 463-471 (2019).

Location

Building: François Jacob
Room: Auditorium Centre François Jacob
Address: 28 Rue du Docteur Roux, Paris, France