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© Research
Event

“Genetic and epigenetic determinants of population differences in immune response to infections” by Luis BARREIRO – Genomes and Genetics departemental seminar

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
12
Apr 2018
Time
11:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: MONOD Room: Amphi JACQUES MONOD
Location
2018-04-12 11:00:00 2018-04-12 12:30:00 Europe/Paris “Genetic and epigenetic determinants of population differences in immune response to infections” by Luis BARREIRO – Genomes and Genetics departemental seminar Speaker: Luis Barreiro, PhD.  Assistant Professor  CHU Sainte-Justine/University of Montreal   Canadian Research Chair in Functional and Evolutionary  Genomics of the Immune System. Montreal Canada   Abstract: Infectious diseases have always been a major health […] Institut Pasteur, Rue du Docteur Roux, Paris, France Ludovic Tailleux ludovic.tailleux@pasteur.fr

About

Speaker:

Luis Barreiro, PhD.  Assistant Professor 

CHU Sainte-Justine/University of Montreal  

Canadian Research Chair in Functional and Evolutionary 

Genomics of the Immune System.

Montreal Canada

 

Abstract:
Infectious diseases have always been a major health problem throughout the world, imposing strong selective pressure on the human genome. Despite the recent development of vaccines and antibiotics, there are still nearly 15 million deaths every year attributable to the effects of infectious diseases. Although genetic studies of infectious diseases have identified important pathways involved in protective immunity, very little is known about the underlying genetic and evolutionary factors contributing to differences in susceptibility to infectious diseases at the population level. In this talk, I will discuss the importance of host genetic and epigenetic factors in shaping population differences in innate immune responses to infectious agents. I will also discuss recent findings from our lab showing that BCG can be used to reprogram hematopoietic stem cells (HSC) to generate protective innate immunity against tuberculosis. Our results indicate that targeting the HSC compartment provides a novel approach for vaccine development. 

Location

Building: MONOD
Room: Amphi JACQUES MONOD
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France