Alessia BUSCAINO – University of Kent-UK – School of Biosciences Kent Fungal Group
Fungal pathogens are a threat to human health because of their ability to thrive in different environmental niches, together with the rising occurrence of anti-fungal drugs resistance. Candida albicans is the most common human fungal pathogen. It colonises almost every organ in the human body where it causes life-threating infections. The ability to survive in different environments is partly due its remarkable genomic plasticity that is promoted by environmental stresses. Mechanisms underlying C. albicans genome plasticity are unknown but it is clear that DNA repeats play an essential role in this process. In many organisms, genome stability at DNA repeats is ensured by the assembly of heterochromatin structures inhibitory to recombination. Surprisingly, the chromatin state of C. albicans DNA repeats and its function in regulating genome plasticity is still largerly unknown. Our research focuses on chromatin structure and function in Candida albicans. We aim to determine the chromatin state associated with C. albicans DNA repeats and to understand whether and how chromatin regulates genome plasticity in this important human fungal pathogen.
Link to your website: https://www.kentfungalgroup.com/dr-alessia-buscaino
Contact : Mélanie Legrand (firstname.lastname@example.org)