Epigenetics and Genome plasticity in the human fungal pathogen Candida albicans – Alessia Buscaino | Research - Institut Pasteur

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Didier Payen de la Garanderie Seminar : “Severe sepsis: the phases that may lead the therapeutic strategies” Infection & Epidemiology department

HDR ( Habilitation à diriger des recherches)

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Diseases

Organisms

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Technique

Date

22

Jan 2018

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14:00:00

Institut Pasteur, Rue du Docteur Roux, Paris, France

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2018-01-22 14:00:00 2018-01-22 15:00:00 Europe/Paris Epigenetics and Genome plasticity in the human fungal pathogen Candida albicans – Alessia Buscaino Alessia BUSCAINO – University of Kent-UK – School of Biosciences Kent Fungal Group Fungal pathogens are a threat to human health because of their ability to thrive in different environmental niches, together with the […] Institut Pasteur, Rue du Docteur Roux, Paris, France Mélanie Legrand melanie.legrand@pasteur.fr

About

Alessia BUSCAINO – University of Kent-UK – School of Biosciences Kent Fungal Group

Fungal pathogens are a threat to human health because of their ability to thrive in different environmental niches, together with the rising occurrence of anti-fungal drugs resistance. Candida albicans is the most common human fungal pathogen. It colonises almost every organ in the human body where it causes life-threating infections. The ability to survive in different environments is partly due its remarkable genomic plasticity that is promoted by environmental stresses. Mechanisms underlying C. albicans genome plasticity are unknown but it is clear that DNA repeats play an essential role in this process. In many organisms, genome stability at DNA repeats is ensured by the assembly of heterochromatin structures inhibitory to recombination. Surprisingly, the chromatin state of C. albicans DNA repeats and its function in regulating genome plasticity is still largerly unknown. Our research focuses on chromatin structure and function in Candida albicans. We aim to determine the chromatin state associated with C. albicans DNA repeats and to understand whether and how chromatin regulates genome plasticity in this important human fungal pathogen.

Link to your website: https://www.kentfungalgroup.com/dr-alessia-buscaino

http://www.kent.ac.uk/bio/profiles/staff/buscaino.html

Contact : Mélanie Legrand (melanie.legrand@pasteur.fr)

Location

Address: Institut Pasteur, Rue du Docteur Roux, Paris, France

Published on: 10 Jan 2018 • Modified on: 18 Dec 2018

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