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© Research
Event

Developmental and Stem Cell Biology seminar by Dr. Ritwick Sawarkar, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
08
Feb 2019
Time
11:00:00
25 Rue du Dr Roux, Paris, France
Address
Building: Metchnikoff (#67) Room: Salle Jules Bordet
Location
2019-02-08 11:00:00 2019-02-08 00:00:00 Europe/Paris Developmental and Stem Cell Biology seminar by Dr. Ritwick Sawarkar, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany Friday, February 8th 11:00 am – Jules Bordet meeting room, Metchnikoff building  “Feeling the heat at chromatin: transcriptional response to stress” Invited Speaker: Ritwick Sawarkar Max Planck Institute of Immunobiology and Epigenetics Freiburg, Germany […] 25 Rue du Dr Roux, Paris, France Christian Muchardt christian.muchardt@pasteur.fr

About

Friday, February 8th
11:00 am – Jules Bordet meeting room, Metchnikoff building

 “Feeling the heat at chromatin: transcriptional response to stress”

Invited Speaker: Ritwick Sawarkar
Max Planck Institute of Immunobiology and Epigenetics
Freiburg, Germany

Abstract: Metazoan cells react to environmental stress by mounting a rapid and reversible response of global transcriptional downregulation along with induction of a small number of stress-response genes. This classical phenomenon raises three key questions: (i) how is the stress sensed in the cytosol? (ii) What are the effectors of the transcriptional downregulation in the nucleus? (iii) How are the cytosolic stress sensors linked to nuclear transcriptional effectors? In the process of answering these simple questions, we have linked protein quality control in the cytoplasm to RNA polymerase activity in the nucleus via kinase cascades. Our studies uncovered chromatin-based regulation via phase separation of transcriptional regulatory complexes. Recent advances in our understanding of how cells re-program their regulatory network to deal with stress will be presented.

 

Location

Building: Metchnikoff (#67)
Room: Salle Jules Bordet
Address: 25 Rue du Dr Roux, Paris, France