“PRC2: versatile transcriptional regulators during pre-implantation development of the mouse”
In mammals, fusion of two highly differentiated gametes gives rise to a totipotent zygote capable of developing into a whole organism. The switch in cell fate coincides with translation and degradation of maternally provided transcripts, initiation of global transcription called zygotic genome activation (ZGA), and “epigenetic reprogramming” of germline chromatin states into an embryonic state, occurring in part in a parent-of-origin specific manner.
My laboratory is interested in the role of Polycomb Group (PcG) proteins and associated chromatin states in gene regulation in the germ line, in pre-implantation embryos and in intergenerational epigenetic inheritance. I will discuss our ongoing research in addressing these questions.