Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Clinical Research Assistant
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Clinical Research Assistant
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research
Event

“Clathrin plaques and associated dynamin 2 organize a mechanosensitive compartment” – Stéphane Vassilopoulos

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
25
Sep 2017
Time
12:00:00
28 Rue du Docteur Roux, Paris, France
Address
Building: François Jacob Room: Auditorium François Jacob
Location
2017-09-25 12:00:00 2017-09-25 17:00:00 Europe/Paris “Clathrin plaques and associated dynamin 2 organize a mechanosensitive compartment” – Stéphane Vassilopoulos Séminaire  “Clathrin plaques and associated dynamin 2 organize a mechanosensitive compartment”   présenté par Stéphane Vassilopoulos (Myologie Centre de Recherche / Institut de Myologie – Paris) Lundi 25 septembre 2017 à 12h00  Auditorium F. […] 28 Rue du Docteur Roux, Paris, France Arnaud Echard arnaud.echard@pasteur.fr

About

Séminaire

 “Clathrin plaques and associated dynamin 2 organize a mechanosensitive compartment

 

présenté par Stéphane Vassilopoulos

(Myologie Centre de Recherche / Institut de Myologie – Paris)

Lundi 25 septembre 2017 à 12h00

 Auditorium F. Jacob

 

Invité par Arnaud Echard

contact: arnaud.echard@pasteur.fr

 

Abstract :

Large flat clathrin lattices, clathrin plaques, are stable features of the plasma membrane observed in several cell types. They have been associated with sites of strong adhesion suggesting that they could also play a role in force transduction. Here, I will present our work on a compartment composed of clathrin plaques and associated branched actin and demonstrate its requirement for the formation of a three-dimensional intermediate filament web in humans and mice. Importantly, clathrin plaques and associated actin also act as signalling platforms for mechanical stress-induced YAP activity. We show that dynamin 2 participates in clathrin plaque articulation with branched actin filaments and that centronuclear myopathy mutations cause severe plaque and cytoskeleton disorganization and defective mechanical sensing. Together, our data suggest that clathrin plaques, dynamin 2 and associated actin act as platforms for both mechanical signal sensing and transduction which could play an important role in the connection between nuclei and the extracellular matrix. 

Accueil

Location

Building: François Jacob
Room: Auditorium François Jacob
Address: 28 Rue du Docteur Roux, Paris, France