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« Coopération de la phosphoprotéine et de la protéine de matrice du virus de la rage dans la modulation des voies de signalisation Jak/Stat et NF-kB et développement d’une approche thérapeutique » Soutenance de thèse par Florian Sonthonnax

Seminar of the Infection & Epidemiology Department with Prof. Dr. Karl-Klaus Conzelmann – “Sensing of rabies virus by innate immune receptors and PKR”

© Research

Event

“Clathrin plaques and associated dynamin 2 organize a mechanosensitive compartment” – Stéphane Vassilopoulos

Team: Membrane Traffic and Cell Division

Department of: Cell Biology & Infection

Member: Arnaud Echard

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

25

Sep 2017

Time

12:00:00

28 Rue du Docteur Roux, Paris, France

Address

Building: François Jacob

Location

2017-09-25 12:00:00 2017-09-25 17:00:00 Europe/Paris “Clathrin plaques and associated dynamin 2 organize a mechanosensitive compartment” – Stéphane Vassilopoulos Séminaire “Clathrin plaques and associated dynamin 2 organize a mechanosensitive compartment” présenté par Stéphane Vassilopoulos (Myologie Centre de Recherche / Institut de Myologie – Paris) Lundi 25 septembre 2017 à 12h00 Auditorium F. […] 28 Rue du Docteur Roux, Paris, France Arnaud Echard arnaud.echard@pasteur.fr

About

Séminaire

“Clathrin plaques and associated dynamin 2 organize a mechanosensitive compartment”

présenté par Stéphane Vassilopoulos

(Myologie Centre de Recherche / Institut de Myologie – Paris)

Lundi 25 septembre 2017 à 12h00

Auditorium F. Jacob

Invité par Arnaud Echard

contact: arnaud.echard@pasteur.fr

Abstract :

Large flat clathrin lattices, clathrin plaques, are stable features of the plasma membrane observed in several cell types. They have been associated with sites of strong adhesion suggesting that they could also play a role in force transduction. Here, I will present our work on a compartment composed of clathrin plaques and associated branched actin and demonstrate its requirement for the formation of a three-dimensional intermediate filament web in humans and mice. Importantly, clathrin plaques and associated actin also act as signalling platforms for mechanical stress-induced YAP activity. We show that dynamin 2 participates in clathrin plaque articulation with branched actin filaments and that centronuclear myopathy mutations cause severe plaque and cytoskeleton disorganization and defective mechanical sensing. Together, our data suggest that clathrin plaques, dynamin 2 and associated actin act as platforms for both mechanical signal sensing and transduction which could play an important role in the connection between nuclei and the extracellular matrix.

Accueil

Location

Building: François Jacob
Address: 28 Rue du Docteur Roux, Paris, France

Published on: 28 Jun 2017 • Modified on: 08 Sep 2017

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