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© Research
Event

C3BI Seminar – Emergence of de novo protein coding genes from ‘dark genomic matter’ — fact or fiction?

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
06
Sep 2017
Time
14:00:00
Institut Pasteur, Paris, France
Address
Building: Batiment François Jacob
Location
2017-09-06 14:00:00 2017-09-06 15:00:00 Europe/Paris C3BI Seminar – Emergence of de novo protein coding genes from ‘dark genomic matter’ — fact or fiction? EMERGENCE OF DE NOVO PROTEIN CODING GENES FROM ‘DARK GENOMIC MATTER’ — FACT OR FICTION?  Main speaker : Erich Bornberg-Bauer, from Institute for Evolution and Biodiversity, The Westfalian Wilhelms University of Muenster, Germany  Date : 06/09/2017 […] Institut Pasteur, Paris, France Christophe Becavin christophe.becavin@pasteur.fr

About

EMERGENCE OF DE NOVO PROTEIN CODING GENES FROM ‘DARK GENOMIC MATTER’ — FACT OR FICTION?


 Main speaker : Erich Bornberg-Bauer, from Institute for Evolution and Biodiversity, The Westfalian Wilhelms University of Muenster, Germany  Date : 06/09/2017 at 02:00 pm  Location : Auditorium Francois Jacob – BIME (26) ,Institut Pasteur, Paris


Proteins are the workhorses of the cell and, over billions of years, they have evolved an amazing plethora of extremely diverse and versatile structures with equally diverse functions. Therefore, their evolution echoes the evolution of all forms of life. Evolutionary emergence of new proteins and transitions between existing ones are widely believed to be rare or even impossible. However, recent advances in comparative genomics have repeatedly called some 10%-30% of all genes without any detectable similarity to existing proteins. Even after careful scrutiny, some of those “orphan” genes contain protein coding reading frames with detectable transcription and translation. Thus some proteins seem to have emerged from previously non-coding ‘dark genomic matter’. These ‘de novo’ proteins tend to be disordered, fast evolving, weakly expressed but also rapidly assuming novel and physiologically important functions. I will review mechanisms by which ‘de novo’ proteins might be created, under which circumstances they may become fixed and why they are elusive. I will present a couple of studies which mostly focus on metazoan genomes.


Due to security policy in Institut Pasteur, please register before if you plan to come to this meeting

Location

Building: Batiment François Jacob
Address: Institut Pasteur, Paris, France