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© Research
Publication : Brain structure & function

Brain volumes and Val66Met polymorphism of the BDNF gene: local or global effects?

Team: Applied and Theoretical Neuroanatomy
Member: Roberto Toro
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Brain structure & function - 01 Oct 2009

Toro R, Chupin M, Garnero L, Leonard G, Perron M, Pike B, Pitiot A, Richer L, Veillette S, Pausova Z, Paus T,

Link to Pubmed [PMID] – 19205731

Link to DOI – 10.1007/s00429-009-0203-y

Brain Struct Funct 2009 Oct; 213(6): 501-9

A common Single-Nucleotide Polymorphism in the Brain-Derived Neurotrophic Factor (BDNF) gene coding the Val66Met substitution in the pro-BDNF protein has been associated with a number of behavioural and neuroanatomical phenotypes; the latter include, for example, regional differences in volumes of the hippocampus and prefrontal grey matter. Here, we show that the observed regional differences may not stem from a localised effect of this gene. Our analysis of regional brain volume in a cohort of 331 adolescents indicates that the Val66Met substitution has a global effect on brain volume, and that the observed local differences are to be expected if brain allometry-the covariance pattern of regional brain volumes-is taken into account.