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DPT NEUROSCIENCE – Thesis defence : Mariano GENERA – Structural and functional study of the human phosphatase PTPN3 and its interaction with oncogenic viruses.

Department of Immunology seminar: Niklas Björkström, Differentiation, residency, and recirculation patterns of human tissue NK cells

© Research

Event

Lab Seminar: Layer and Cell Type-Specific Modulation of Neocortical Neuronal Microcircuits

Team: Neural Circuit Dynamics and Decision Making

Department of: Neuroscience

Member: Florent Haiss

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

19

Nov 2019

Time

11:30:00

25 Rue du Dr Roux, 75015 Paris, France

Address

Building: Fernbach (68)

Location

2019-11-19 11:30:00 2019-11-19 12:30:00 Europe/Paris Lab Seminar: Layer and Cell Type-Specific Modulation of Neocortical Neuronal Microcircuits The function of neocortical excitatory and inhibitory neurons is under constant control of neuromodulators such as acetylcholine, noradrenaline, dopamine, serotonin and adenosine. Some of these neuromodulatory transmitters (e.g. acetylcholine) can activate ligand-gated ion channels; […] 25 Rue du Dr Roux, 75015 Paris, France Florent Haiss florent.haiss@pasteur.fr

Speakers

(Forschungszentrum Juelich)

About

The function of neocortical excitatory and inhibitory neurons is under constant control of neuromodulators such as acetylcholine, noradrenaline, dopamine, serotonin and adenosine. Some of these neuromodulatory transmitters (e.g. acetylcholine) can activate ligand-gated ion channels; however, most act via G-protein coupled receptors which alter the excitability of neurons but also the synaptic release probability. Using patch-clamp recordings and correlated morphological analysis we have studied the effects of several neuromodulators, in particular those of adenosine (a product of ATP degradation) and acetylcholine. We found that their effects are highly cell-specific leading to up- or down-regulation of the excitability of identified neuron types and the synaptic transmission between them. These effects can be exerted at low concentrations and over relatively large distances, thereby altering the cortical-subcortical signal flow.

Contact: Florent Haiss – florent.haiss@pasteur.fr

Location

Building: Fernbach (68)
Address: 25 Rue du Dr Roux, 75015 Paris, France

Published on: 13 Nov 2019

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