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© Institut Pasteur et Institut Imagine
Scanning electron micrograph of segmented filamentous bacterium (SFB). Segmented filamentous bacteria (SFB) are bacteria from the Clostridiaceae family that colonize the intestines of many species, likely including humans, without causing disease; they live in symbiosis with epithelial cells and are involved in the maturation of intestinal immunity.
Publication : Microbiology spectrum

Customizing Host Chromatin: a Bacterial Tale

Team: Chromatin and Infection
Member: Michael Connor
Member: Mélanie Hamon
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbiology spectrum - 01 Mar 2019

Connor M, Arbibe L, Hamon M

Link to Pubmed [PMID] – 30953433

Microbiol Spectr 2019 03;7(2)

Successful bacterial colonizers and pathogens have evolved with their hosts and have acquired mechanisms to customize essential processes that benefit their lifestyle. In large part, bacterial survival hinges on shaping the transcriptional signature of the host, a process regulated at the chromatin level. Modifications of chromatin, either on histone proteins or on DNA itself, are common targets during bacterium-host cross talk and are the focus of this article.