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  • Undergraduate Student
  • Veterinary
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  • Director of Center
  • Director of Department
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© Research
Publication : Science (New York, N.Y.)

Optimization of virulence functions through glucosylation of Shigella LPS

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 25 Feb 2005

West NP, Sansonetti P, Mounier J, Exley RM, Parsot C, Guadagnini S, Prévost MC, Prochnicka-Chalufour A, Delepierre M, Tanguy M, Tang CM

Link to Pubmed [PMID] – 15731456

Science 2005 Feb;307(5713):1313-7

Shigella, the leading cause of bacillary dysentery, uses a type III secretion system (TTSS) to inject proteins into human cells, leading to bacterial invasion and a vigorous inflammatory response. The bacterium is protected against the response by the O antigen of lipopolysaccharide (LPS) on its surface. We show that bacteriophage-encoded glucosylation of Shigella O antigen, the basis of different serotypes, shortens the LPS molecule by around half. This enhances TTSS function without compromising the protective properties of the LPS. Thus, LPS glucosylation promotes bacterial invasion and evasion of innate immunity, which may have contributed to the emergence of serotype diversity in Shigella.