“Conserved machinery underlying malaria parasite virulence in rodents and humans” | Research - Institut Pasteur

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Seminaire conjoint du departement d’immunologie et departement de biologie du développement & cellules souches

Santa Barbara Advanced School of Quantitative Biology

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

16

Jun 2016

Time

12:00:00

Institut Pasteur, Rue du Docteur Roux, Paris, France

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Building: Lwoff

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2016-06-16 12:00:00 2016-06-16 18:00:00 Europe/Paris “Conserved machinery underlying malaria parasite virulence in rodents and humans” Volker HEUSSLER – Institute of Cell Biology (Bern – Suisse) Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. […] Institut Pasteur, Rue du Docteur Roux, Paris, France Chetan Chitnis chetan.chitnis@pasteur.fr

About

Volker HEUSSLER – Institute of Cell Biology (Bern – Suisse)

Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. A similar phenomenon has been observed in mouse models of malaria, using the rodent parasite Plasmodium berghei, but it is unclear whether the P. falciparum proteins known to be involved in this process are conserved in the rodent parasite. Here we identify the P. berghei orthologues of two such key factors of P. falciparum, SBP1 and MAHRP1. Red blood cells infected with P. berghei parasites lacking SBP1 or MAHRP1a fail to bind the endothelial receptor CD36 and show reduced sequestration and virulence in mice. Complementation of the mutant P. berghei parasites with the respective P. falciparum SBP1 and MAHRP1 orthologues restores seques- tration and virulence. These findings reveal evolutionary conservation of the machinery underlying sequestration of divergent malaria parasites and support the notion that the P. berghei rodent model is an adequate tool for research on malaria virulence.

Site web du laboratoire : http://www.izb.unibe.ch/research/prof_dr_volker_heussler/index_eng.html

Contact : Chetan CHITNIS (chetan.chitnis@pasteur.fr – Poste 94.28)

Location

Building: Lwoff
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France

Published on: 06 Jun 2016 • Modified on: 25 Sep 2017

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