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© Research
Event

“Conserved machinery underlying malaria parasite virulence in rodents and humans”

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
16
Jun 2016
Time
12:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: Lwoff
Location
2016-06-16 12:00:00 2016-06-16 18:00:00 Europe/Paris “Conserved machinery underlying malaria parasite virulence in rodents and humans” Volker HEUSSLER – Institute of Cell Biology (Bern – Suisse) Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. […] Institut Pasteur, Rue du Docteur Roux, Paris, France Chetan Chitnis chetan.chitnis@pasteur.fr

About

DSC00988Volker HEUSSLERInstitute of Cell Biology (Bern Suisse)

Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. A similar phenomenon has been observed in mouse models of malaria, using the rodent parasite Plasmodium berghei, but it is unclear whether the P. falciparum proteins known to be involved in this process are conserved in the rodent parasite. Here we identify the P. berghei orthologues of two such key factors of P. falciparum, SBP1 and MAHRP1. Red blood cells infected with P. berghei parasites lacking SBP1 or MAHRP1a fail to bind the endothelial receptor CD36 and show reduced sequestration and virulence in mice. Complementation of the mutant P. berghei parasites with the respective P. falciparum SBP1 and MAHRP1 orthologues restores seques- tration and virulence. These findings reveal evolutionary conservation of the machinery underlying sequestration of divergent malaria parasites and support the notion that the P. berghei rodent model is an adequate tool for research on malaria virulence.

Site web du laboratoire : http://www.izb.unibe.ch/research/prof_dr_volker_heussler/index_eng.html

Contact :  Chetan CHITNIS (chetan.chitnis@pasteur.fr – Poste 94.28)

Location

Building: Lwoff
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France