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Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
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Addition of N-glycosylation sites on the globular head of the H5 hemagglutinin induces the escape of highly pathogenic avian influenza A H5N1 viruses from vaccine-induced immunity

Agrégation de classements avec égalités: algorithmes, guides à l’utilisateur et applications aux données biologiques

© Research

Publication : Antimicrobial agents and chemotherapy

Fitness Studies of Azole-Resistant Strains of Aspergillus fumigatus

Team: Archived: Aspergillus

Team: Archived: Nuclear Magnetic Resonance Of Biomolecules

Member: Rémi Beau

Member: Jean-Paul Latge

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Antimicrobial agents and chemotherapy - 28 Sep 2015

Valsecchi I, Mellado E, Beau R, Raj S, Latgé JP

Link to Pubmed [PMID] – 26416854

Antimicrob. Agents Chemother. 2015 Dec;59(12):7866-9

Isogenic bar-coded strains of Aspergillus fumigatus carrying the G54W or M220K mutation in Cyp51A were constructed. In vitro, the growth and conidiation capacities of the mutants were similar to those of the parental strain. Competition studies in the absence of azoles showed that there was no adverse fitness cost for the azole-resistant A. fumigatus strains in vitro or in vivo compared to the parental strain.

Published on: 28 Sep 2015 • Modified on: 28 Sep 2017