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  • Director of Center
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About

I am currently leading the Insect Immunity & Infection group within the Virology Department and the Insect-Virus Interactions Unit. Our primary focus is to understand interactions between Aedes aegypti mosquitoes and the arboviruses they transmit to humans (i.e. dengue viruses, Zika virus, Chikungunya virus). In particular, we aim to understand the molecular mechanisms underlying natural resistance or susceptibility of field-derived mosquito colonies to dengue viruses, using approaches combing single-cell comics and CRISPR-Cas9 genome editing tools. 

For further information, please visit: www.merklinglab.fr

 

Projects

Project
Completed
3 Members

ANR BAKOUMBA: Dissecting the genetic basis of a natural dengue resistance phenotype in the mosquito Aedes aegypti

Louis Lambrechts (PI)

Dengue viruses (DENVs) and their main mosquito vector Aedes aegypti are responsible for the most rapidly advancing arboviral disease of humans. Mosquito susceptibility to DENV infection is a quantitative trait that varies between and […]
Project
Completed
7 Members

Functional characterization of mosquito genes involved in dengue virus transmission identified by RNA-seq at the individual midgut level

Louis Lambrechts (PI)

Dengue is the most rapidly expanding, globally dominant arthropod-borne (arbo) viral disease. It affects close to 400 million people each year in more than 125 countries. Recent reports of autochtonous cases in Southern France […]

CV

Academic Education

2010-2015 PhD Degree in Virology and Immunology Radboud Institute for Molecular Life Sciences Department of Medical Microbiology Radboud University, Nijmegen, The Netherlands

2008-2010 Master Degree in Molecular Biology, Cell Biology and Immunology Université de Strasbourg, France

2005-2008 Bachelor Degree in Cell Biology and Physiology Université de Strasbourg, France

Research experience

Since November 2020 Assistant professor within the Interactions Virus-Insect Unit, Virology department, Institut Pasteur, CNRS UMR 2000

December 2015-October 2020 Post-doctoral researcher Institut Pasteur, Paris, France Supervisor: Dr. Louis Lambrechts Topic: Functional genomics of dengue virus transmission by Aedes mosquitoes.

December 2010-September 2015 PhD student Radboud University Medical Center, Nijmegen, The Netherlands Supervisor: Dr. Ronald van Rij Topic: Antiviral resistance and tolerance in Drosophila

July 2009-July 2010 2nd Master apprenticeship Institute of Cellular and Molecular Biology (IBMC), Strasbourg, France Supervisors: Pr. Jules Hoffmann and Dr. Hidehiro Fukuyama Topic: Immunity against Alzheimer’s disease in Drosophila

Fellowships and Awards

2022 ERC Starting Grant

2021 ANR JC/JC (Young Investigator) Grant

2020 Labex IBEID Springboard to Independence Grant

2018 L’Oréal-UNESCO For Women in Science Award

2018 ACME Young Investigator Travel Award

2018 Best Oral Presentation Award Virology day, Institut Pasteur, Paris

2017 Pasteur-Roux Post-doctoral Fellowship Grant

Publications

>Pubmed link. 

Publications

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