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© Research
Publication : PloS one

Gαo is required for L-canavanine detection in Drosophila.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 01 Jan 2013

Devambez I, Ali Agha M, Mitri C, Bockaert J, Parmentier ML, Marion-Poll F, Grau Y, Soustelle L

Link to Pubmed [PMID] – 23671680

Link to HAL – hal-01408197

Link to DOI – 10.1371/journal.pone.0063484

PLoS One 2013 ; 8(5): e63484

Taste is an essential sense for the survival of most organisms. In insects, taste is particularly important as it allows to detect and avoid ingesting many plant toxins, such as L-canavanine. We previously showed that L-canavanine is toxic for Drosophila melanogaster and that flies are able to detect this toxin in the food. L-canavanine is a ligand of DmXR, a variant G-protein coupled receptor (GPCR) belonging to the metabotropic glutamate receptor subfamily that is expressed in bitter-sensitive taste neurons of Drosophila. To transduce the signal intracellularly, GPCR activate heterotrimeric G proteins constituted of α, β and γ subunits. The aim of this study was to identify which Gα protein was required for L-canavanine detection in Drosophila. By using a pharmacological approach, we first demonstrated that DmXR has the best coupling with Gαo protein subtype. Then, by using genetic, behavioral assays and electrophysiology, we found that Gαo47A is required in bitter-sensitive taste neurons for L-canavanine sensitivity. In conclusion, our study revealed that Gαo47A plays a crucial role in L-canavanine detection.