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© Bruno Dupuy, Claire Morvan, Institut Pasteur
Cellules végétative et spores de Clostridioides difficile / Vegative cells and spores of Clostridioides difficile
Publication : Antimicrobial agents and chemotherapy

Molecular drug susceptibility testing and genotyping of Mycobacterium leprae strains from South America

Team: Pathogenesis of Bacterial Anaerobes
Member: Marc Monot
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 28 Mar 2011

Singh P, Busso P, Paniz-Mondolfi A, Aranzazu N, Monot M, Honore N, de Faria Fernandes Belone A, Virmond M, Villarreal-Olaya ME, Rivas C, Cole ST

Link to Pubmed [PMID] – 21444694

Antimicrob. Agents Chemother. 2011 Jun;55(6):2971-3

Possible drug resistance in Mycobacterium leprae strains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two of the three strains from relapsed cases contained dapsone resistance mutations, and one strain also harbored a rifampin resistance mutation. Single nucleotide polymorphism analysis of these strains revealed five subtypes: 3I (73.8%), 4P (11.6%), 1D (6.9%), 4N (6%), and 4O (1.7%).