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© Research
Publication : Archivum immunologiae et therapiae experimentalis

V gene replacement in T and B lymphocytes: illicit or regimented rearrangement?

Team: Group: ILC development and inflammation
Team: Archived: Lymphocytes and Immunity
Member: Rachel Golub
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Archivum immunologiae et therapiae experimentalis - 01 Jan 2002

Golub R

Link to Pubmed [PMID] – 12371621

Arch. Immunol. Ther. Exp. (Warsz.) 2002;50(4):255-62

Lymphocytes can undergo novel types of secondary genetic rearrangements that alter the specificity of a pre-existing B cell receptor (BCR) or T cell receptor (TCR). V gene replacement is one of them and it replaces an already rearranged V gene segment with an upstream germline V gene segment. This review focuses on the molecular aspect of rearrangement. The role of this mechanism in the immune system is debated.