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© Research
Publication : Trends in parasitology

Plasmodium sex determination and transmission to mosquitoes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in parasitology - 01 Jan 2002

Paul RE, Brey PT, Robert V

Link to Pubmed [PMID] – 11850012

Trends Parasitol. 2002 Jan;18(1):32-8

In order to be transmitted by their mosquito vector, malaria parasites undergo sexual reproduction, which occurs between specialized male and female parasites (gametes) within the blood meal in the mosquito. Nothing was known about how Plasmodium determines the sex of its gametocytes (gamete precursors), which are produced in the vertebrate host. Recently, erythropoietin, the vertebrate hormone controlling erythropoiesis in response to anaemia, was implicated in Plasmodium sex determination in animal models of malaria. This review examines the available information and addresses the relevance of such a sex determining mechanism for Plasmodium falciparum transmission to mosquitoes, with special reference to low gametocytaemias.

http://www.ncbi.nlm.nih.gov/pubmed/11850012