Lien vers Pubmed [PMID] – 12371621
Arch. Immunol. Ther. Exp. (Warsz.) 2002;50(4):255-62
Lymphocytes can undergo novel types of secondary genetic rearrangements that alter the specificity of a pre-existing B cell receptor (BCR) or T cell receptor (TCR). V gene replacement is one of them and it replaces an already rearranged V gene segment with an upstream germline V gene segment. This review focuses on the molecular aspect of rearrangement. The role of this mechanism in the immune system is debated.