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© Melanie Blokesch, EPFL
Flagellated Vibrio cholerae
Publication : Research in microbiology

Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli

Team: Bacterial Genome Plasticity
Member: Didier Mazel
Member: Zeynep Baharoglu
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Research in microbiology - 16 Jun 2014

Baharoglu Z, Mazel D

Link to Pubmed [PMID] – 24946128

Res. Microbiol. 2014 Jul-Aug;165(6):476-80

Low concentrations of aminoglycosides induce the SOS response in Vibrio cholerae but not in Escherichia coli. In order to determine whether a specific factor present in E. coli prevents this induction, we developed a genetic screen where only SOS inducing mutants are viable. We identified the vsr gene coding for the Vsr protein of the very short patch mismatch repair (VSPR) pathway. The effect of mismatch repair (MMR) mutants was also studied. We propose that lesions formed upon aminoglycoside treatment are preferentially repaired by VSPR without SOS induction in E. coli and by MMR when VSPR is impaired.