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Assistant Professor
Associate Professor
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Clinical Research Nurse
Clinician Researcher
Department Manager
Dual-education Student
Full Professor
Honorary Professor
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Master Student
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Nursing Staff
Permanent Researcher
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PhD Student
Physician
Post-doc
Prize
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

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Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

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Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile

The carboxy-terminal αN helix of the archaeal XerA tyrosine recombinase is a molecular switch to control site-specific recombination

Publication : Journal of assisted reproduction and genetics

Effect of temozolomide on male gametes: an epigenetic risk to the offspring?

Team: Human Developmental Genetics

Member: Kenneth McElreavey

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Journal of assisted reproduction and genetics - 08 May 2013

Berthaut I, Montjean D, Dessolle L, Morcel K, Deluen F, Poirot C, Bashamboo A, McElreavey K, Ravel C

Link to Pubmed [PMID] – 23652788

J. Assist. Reprod. Genet. 2013 Jun;30(6):827-33

Temozolomide is an oral alkylating agent with proven efficacy in recurrent high-grade glioma. The antitumour activity of this molecule is attributed to the inhibition of replication through DNA methylation. However, this methylation may also perturb other DNA-dependent processes, such as spermatogenesis. The ability to father a child may be affected by having this treatment. Here we report a pregnancy and a baby born after 6 cures of temozolomide.

Published on: 08 May 2013