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© Research
Publication : Current opinion in genetics & development

Cell polarity: the ups and downs of the Par6/aPKC complex

Team: Dynamics of Developmental Decisions in Drosophila
Member: François Schweisguth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in genetics & development - 01 Aug 2003

Henrique D, Schweisguth F

Link to Pubmed [PMID] – 12888006

Curr. Opin. Genet. Dev. 2003 Aug;13(4):341-50

A signaling complex in which atypical protein kinase C associates with a regulatory protein, Par6, plays an essential role in establishing cell polarity. Recent studies in organisms ranging from worms to mammals have highlighted some of the conserved mechanisms by which the assembly, localization and activity of this complex are regulated. Recent work is also beginning to unravel how this complex acts in concert with additional molecular complexes to establish and maintain polarity.