About
Collaborations: Inrae (E Vergu et B Laroche), UVSQ (JL Herrmann)
Summary: The human microbiota plays major roles in host infections. It can impact host susceptibility, infection outcome and acquisition of pathogens.
This project aims at encompassing the within-host and the between-host scales in order to study their interplay in the acquisition and transmission of pathogenic, specifically antibiotic-resistant bacteria. Through the analysis of epidemiological data and samples collected in several epidemiological cohorts, including nasal samples from the European i-Bird project, and feacal samples from the Parthage ANR project, we aim at (1) characterize the community assembly of a microbiota and identify microbial species whose behavior deviates from the neutral processes, (2) model the within-host dynamics of species, to simulate ecological interactions between commensal microorganisms and pathogenic and/or resistant ones (e.g.S. aureus), (3) summarize the information from the community dynamics taking place in order to assess host pathogen susceptibility and transmission potential, and (4) encompass within- and between-host dynamics, while considering inter-individual heterogeneities, in a single model describing the impact of host-to-host contacts on the diffusion of a pathogen in the population.
Funding: ANR, Inception
