Timeline

Pierre Charneau

Head of Structure

02 Apr 2024

publication

A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model.

07 Sep 2023

publication

Full eradication of pre-clinical human papilloma virus-induced tumors by a lentiviral vaccine.

18 Apr 2023

publication

Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication.

01 Jan 2023

publication

Preclinical proof of concept of a tetravalent lentiviral T-cell vaccine against dengue viruses.

21 Dec 2022

publication

Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters

14 Sep 2022

publication

A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity.

26 Jul 2022

publication

A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity.

04 Jul 2022

publication

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.

17 Jun 2022

news

New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

27 Apr 2022

publication

An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.

22 Dec 2021

publication

sgDI-tector: defective interfering viral genome bioinformatics for detection of coronavirus subgenomic RNAs

14 Dec 2021

project

Towards understanding of immunostimulatory properties of SARS-CoV-2 RNAs

07 Dec 2021

publication

Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice.

29 Jul 2021

team

Institut Pasteur-TheraVectys Joint Laboratory

26 Jul 2021

news

Humoral immunity to SARS-CoV-2 and seasonal coronaviruses in children and adults in north-eastern France

22 Jul 2021

publication

Humoral immunity to SARS-CoV-2 and seasonal coronaviruses in children and adults in north-eastern France.

21 May 2021

publication

Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance.

18 May 2021

publication

Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies.

01 Apr 2021

publication

SARS-CoV-2 infection in schools in a northern French city: a retrospective serological cohort study in an area of high transmission, France, January to April 2020

01 Jan 2021

publication

High seroprevalence but short-lived immune response to SARS-CoV-2 infection in Paris.

16 Dec 2020

publication

Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models.

02 Sep 2020

publication

A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations

01 Sep 2020

publication

Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France.

18 May 2020

publication

Remodeling of the Core Leads HIV-1 Preintegration Complex into the Nucleus of Human Lymphocytes.

10 Apr 2020

project

CORONABODIES

24 Apr 2018

publication

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

12 Feb 2016

project

Group for AIDS Research

05 Oct 2015

publication

A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad Neutralizing Antibody Response in Pigs

06 Mar 2015

publication

Chromatin organization at the nuclear pore favours HIV replication.

28 Jan 2015

publication

Alternative splicing-regulated protein of hepatitis B virus hacks the TNF-α-stimulated signaling pathways and limits the extent of liver inflammation

11 Dec 2014

publication

Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus

13 Mar 2014

publication

Variable correction of Artemis deficiency by I-Sce1-meganuclease-assisted homologous recombination in murine hematopoietic stem cells

03 Feb 2014

publication

Protective role of LGP2 in influenza virus pathogenesis

10 Nov 2011

publication

Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infection.

25 May 2011

publication

Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis

25 Apr 2011

publication

Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein

21 Jul 2010

publication

Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice

12 Aug 2009

publication

Lentiviral vector-based prime/boost vaccination against AIDS: pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques

01 Jan 2009

publication

Bisarsenical labeling of HIV-1 for real-time fluorescence microscopy

19 Dec 2008

publication

Protective antiviral immunity conferred by a nonintegrative lentiviral vector-based vaccine

22 Oct 2008

publication

Turning astrocytes from the rostral migratory stream into neurons: a role for the olfactory sensory organ

14 Aug 2008

publication

Lack of endogenous TRIM5alpha-mediated restriction in rhesus macaque dendritic cells

07 Jun 2007

publication

HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore

20 Mar 2007

publication

Lentiviral vectors encoding HIV-1 polyepitopes induce broad CTL responses in vivo

01 Dec 2006

publication

A hepatitis C virus (HCV) NS3/4A protease-dependent strategy for the identification and purification of HCV-infected cells

01 Oct 2006

publication

Nuclear import defect of human immunodeficiency virus type 1 DNA flap mutants is not dependent on the viral strain or target cell type

01 Oct 2006

publication

Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexes

26 Jun 2006

publication

Wild-type and central DNA flap defective HIV-1 lentiviral vector genomes: intracellular visualization at ultrastructural resolution levels

01 Mar 2006

publication

A single immunization with a minute dose of a lentiviral vector-based vaccine is highly effective at eliciting protective humoral immunity against West Nile virus

25 Aug 2005

publication

Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function

01 Dec 2004

publication

Histopathological and cognitive defects induced by Nef in the brain

24 Jun 2004

publication

The structure of HIV-1 genomic RNA in the gp120 gene determines a recombination hot spot in vivo

20 May 2004

publication

Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes

01 Jan 2004

publication

A single injection of recombinant measles virus vaccines expressing human immunodeficiency virus (HIV) type 1 clade B envelope glycoproteins induces neutralizing antibodies and cellular immune responses to HIV

01 Feb 2003

publication

G protein-dependent CCR5 signaling is not required for efficient infection of primary T lymphocytes and macrophages by R5 human immunodeficiency virus type 1 isolates

01 Aug 2002

publication

A little guide for advanced search:

A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model.

Full eradication of pre-clinical human papilloma virus-induced tumors by a lentiviral vaccine.

Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication.

Preclinical proof of concept of a tetravalent lentiviral T-cell vaccine against dengue viruses.

Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters

A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity.

A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity.

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.

New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.

sgDI-tector: defective interfering viral genome bioinformatics for detection of coronavirus subgenomic RNAs

Towards understanding of immunostimulatory properties of SARS-CoV-2 RNAs

Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice.

Institut Pasteur-TheraVectys Joint Laboratory

Humoral immunity to SARS-CoV-2 and seasonal coronaviruses in children and adults in north-eastern France

Humoral immunity to SARS-CoV-2 and seasonal coronaviruses in children and adults in north-eastern France.

Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance.

Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies.

SARS-CoV-2 infection in schools in a northern French city: a retrospective serological cohort study in an area of high transmission, France, January to April 2020

High seroprevalence but short-lived immune response to SARS-CoV-2 infection in Paris.

Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models.

A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations

Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France.

Remodeling of the Core Leads HIV-1 Preintegration Complex into the Nucleus of Human Lymphocytes.

CORONABODIES

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

Group for AIDS Research

A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad Neutralizing Antibody Response in Pigs

Chromatin organization at the nuclear pore favours HIV replication.

Alternative splicing-regulated protein of hepatitis B virus hacks the TNF-α-stimulated signaling pathways and limits the extent of liver inflammation

Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus

Variable correction of Artemis deficiency by I-Sce1-meganuclease-assisted homologous recombination in murine hematopoietic stem cells

Protective role of LGP2 in influenza virus pathogenesis

Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infection.

Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis

Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein

Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice

Lentiviral vector-based prime/boost vaccination against AIDS: pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques

Bisarsenical labeling of HIV-1 for real-time fluorescence microscopy

Protective antiviral immunity conferred by a nonintegrative lentiviral vector-based vaccine

Turning astrocytes from the rostral migratory stream into neurons: a role for the olfactory sensory organ

Lack of endogenous TRIM5alpha-mediated restriction in rhesus macaque dendritic cells

HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore

Lentiviral vectors encoding HIV-1 polyepitopes induce broad CTL responses in vivo

A hepatitis C virus (HCV) NS3/4A protease-dependent strategy for the identification and purification of HCV-infected cells

Nuclear import defect of human immunodeficiency virus type 1 DNA flap mutants is not dependent on the viral strain or target cell type

Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexes

Wild-type and central DNA flap defective HIV-1 lentiviral vector genomes: intracellular visualization at ultrastructural resolution levels

A single immunization with a minute dose of a lentiviral vector-based vaccine is highly effective at eliciting protective humoral immunity against West Nile virus

Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function

Histopathological and cognitive defects induced by Nef in the brain

The structure of HIV-1 genomic RNA in the gp120 gene determines a recombination hot spot in vivo

Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes

A single injection of recombinant measles virus vaccines expressing human immunodeficiency virus (HIV) type 1 clade B envelope glycoproteins induces neutralizing antibodies and cellular immune responses to HIV

G protein-dependent CCR5 signaling is not required for efficient infection of primary T lymphocytes and macrophages by R5 human immunodeficiency virus type 1 isolates

Efficient transfer of HTLV-1 tax gene in various primary and immortalized cells using a flap lentiviral vector