Ligne de temps
Christine Petit
Responsable de Structure
18 févr. 2025
publication
Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism.
Lire plus03 août 2024
publication
A free intravesicular C-terminal of otoferlin is essential for synaptic vesicle docking and fusion at auditory inner hair cell ribbon synapses.
Lire plus09 janv. 2024
publication
Extended time frame for restoring inner ear function through gene therapy in Usher1G preclinical model
Lire plus27 juin 2023
publication
Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies.
Lire plus22 déc. 2022
publication
The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses.
Lire plus08 nov. 2021
project
AUDIOGENAGE – Mise au point d’une batterie de tests audiologiques pour le diagnostic de précision de la perte auditive liée à l’âge
Lire plus08 déc. 2020
publication
Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis.
Lire plus01 déc. 2016
publication
An innovative strategy for the molecular diagnosis of Usher syndrome identifies causal biallelic mutations in 93% of European patients
Lire plus27 janv. 2016
publication
High frequency of OTOF mutations in Chinese infants with congenital auditory neuropathy spectrum disorder
Lire plus18 janv. 2016
publication
Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.
Lire plus19 nov. 2015
19 nov. 2015
project
HearDeafTreat Hearing and deafness: molecular mechanisms and therapeutic approaches
Lire plus14 nov. 2015
publication
A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells
Lire plus05 nov. 2015
publication
Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.
Lire plus30 oct. 2015
30 oct. 2015
19 août 2015
publication
EPS8L2 is a new causal gene for childhood onset autosomal recessive progressive hearing loss
Lire plus03 juil. 2015
03 juin 2015
publication
The tip-link molecular complex of the auditory mechano-electrical transduction machinery
Lire plus18 mai 2015
publication
Mutations in apoptosis-inducing factor cause X-linked recessive auditory neuropathy spectrum disorder
Lire plus12 mai 2015
12 mai 2015
23 mars 2015
publication
Whole exome sequencing identifies mutations in Usher syndrome genes in profoundly deaf Tunisian patients
Lire plus15 févr. 2015
publication
Diversity of the causal genes in hearing impaired Algerian individuals identified by whole exome sequencing
Lire plus16 sept. 2014
12 août 2014
publication
Targeted high-throughput sequencing identifies pathogenic mutations in KCNQ4 in two large Chinese families with autosomal dominant hearing loss
Lire plus29 juil. 2014
25 juin 2014
17 juin 2014
publication
The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells
Lire plus13 juin 2014
publication
Whole exome sequencing identifies new causative mutations in Tunisian families with non-syndromic deafness
Lire plus17 avr. 2014
publication
EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness
Lire plus01 mars 2014
publication
The retinal phenotype of Usher syndrome: Pathophysiological insights from animal models Atteinte rétinienne dans le syndrome de Usher : contribution des modèles animaux à la physiopathologie
Lire plus01 oct. 2013
15 sept. 2013
publication
The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route
Lire plus01 juil. 2013
publication
Auditory hair cell centrioles undergo confined Brownian motion throughout the developmental migration of the kinocilium
Lire plus07 juin 2012
publication
Defect in the gene encoding the EAR/EPTP domain-containing protein TSPEAR causes DFNB98 profound deafness
Lire plus21 mars 2011
publication
Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia
Lire plus01 févr. 2011
publication
Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane
Lire plus16 juil. 2010
publication
Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids
Lire plus28 mai 2010
01 avr. 2010
publication
Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape
Lire plus01 déc. 2009
publication
Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses.
Lire plus28 oct. 2009
publication
Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins
Lire plus26 mai 2009
01 mai 2009
publication
Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells
Lire plus08 oct. 2008
13 mars 2008
publication
A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth
Lire plus01 janv. 2008
13 juin 2007
publication
Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.
Lire plus20 oct. 2006
publication
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse.
Lire plus10 janv. 2006
01 juil. 2005
publication
PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa.
Lire plus01 mai 2005
15 avr. 2005
publication
Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells
Lire plus01 févr. 2005
publication
Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly
Lire plus15 sept. 2004
15 avr. 2004
publication
Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells
Lire plus01 mars 2004
20 févr. 2004
publication
Expression of the connexin43- and connexin45-encoding genes in the developing and mature mouse inner ear
Lire plus01 oct. 2003
publication
DFNB40, a recessive form of sensorineural hearing loss, maps to chromosome 22q11.21-12.1
Lire plus01 juil. 2002
publication
Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death
Lire plus01 juin 2002
publication
A subtracted cDNA library from the zebrafish (Danio rerio) embryonic inner ear
Lire plus19 avr. 2002
publication
Anosmin-1, defective in the X-linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons
Lire plus18 avr. 2002
publication
MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes.
Lire plus12 mars 2002
01 mars 2002
publication
DFNB31, a recessive form of sensorineural hearing loss, maps to chromosome 9q32-34
Lire plus01 janv. 2002
01 janv. 2002