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Cassandre is a project of personal database system, integrating a “user-friendly” interface to manage and explore multiple sets of large-scale experimental results in biology. Large-scale experiments that generate quantitative data, such as changes in […]

Biofilms formed by C. albicans on indwelling devices play a major role in the persistence of nosocomial infections, largely because of their elevated tolerance to antifungals. The Fungal Biology and Pathogenicity Unit at Institut […]

Following our introduction of Multi-Locus Sequence Typing (MLST) as the state-of-the-art methodology for molecular epidemiology studies of C. albicans, the Fungal Biology and Pathogenicity Unit at Institut Pasteur is now progressing into population genomics […]

Candida albicans and Candida glabrata are the two major yeast species responsible for invasive fungal infections in humans. Systemic infections due to C. albicans and C. glabrata are associated with high mortality rates despite […]

Cryptococcus neoformans and C. gattii are encapsulated yeasts that can cause life-threatening disease; mainly in immune-suppressed patients, but also in immune-competent individuals. Cryptococcosis affects the lung and may spread to the brain, manifesting itself […]

FunComPath is a network within the Infect-ERA programme (www.infect-era.eu). Infect-ERA is an ERA-Net on human infectious diseases funded under the EU 7th Research Framework Programme (2013 – 2016). It is a continuation of the […]

FunHoMic is a Marie Curie Innovative Training Network that will train 13 Early Stage Researchers and decipher the fungus-host-microbiota interplay to improve the management of fungal infections. FunHoMIc is coordinated by Christophe d’Enfert at […]

The immune system is composed of two arms: the innate and adaptive immunity. Until recently, the adaptive immune system was considered the only mediator of immune memory. However, we and others demonstrated that innate […]

Most Cryptococccus neoformans genes are interrupted by introns, and alternative splicing occurs very often. In order to gain deeper insights into the distribution of introns in the C. neoformans genome, we have used RNA-Seq […]

During the last decade, advances in the sequencing technologies have revealed a large set of new eukaryotic RNA molecules. For instance, whereas 75% of the human genome was recently reported to be transcribed only […]

The Fungal Biology and Pathogenicity Unit at Institut Pasteur is interested in the regulation of the yeast-to-hypha transition in C. albicans because of its role in biofilm formation and, more generally, in virulence. While […]

The enhanced responsiveness observed in human monocytes and mediated by β‑glucan priming is directed towards several other pathogens that are not obligatory fungal-related. This enhanced responsiveness coined training is translated by increased pro-inflammatory cytokines […]

β-glucan, the most abundant fungal cell wall polysaccharide in C. albicans, has gained much attention from the scientific community in the last few decades for its fascinating but not yet fully understood immunobiology. Study […]